scientific evidence supporting cardiac rehabilitation

Cardiac rehabilitation (CR) is a multi-faceted secondary prevention intervention that aims to limit the physiological and psychological effects of cardiovascular disease and to assist in the management of symptoms and a reduction of future cardiovascular risk. Cardiovascular Prevention and Rehabilitation in Practice is a comprehensive, practitioner-focused clinical handbook which provides internationally applicable evidence-based standards of good practice. Cardiac rehabilitation. The official ­recognition of each CR programme by the SCPRS is a prerequisite for reimbursement by healthcare provi­ders.  |  The ESC Textbook of Preventive Cardiology. J Am Coll Cardiol. Owing to barriers linked with programme availability and local or national regulations, further efforts are needed in order to ensure a valid choice of high-quality, evidence-based secondary prevention measures that best fit the patient’s psychosocial situation, cardiovascular risk profile and ­individual preferences. Home-Based Cardiac Rehabilitation: A Scientific Statement From the American Association of Cardiovascular and Pulmonary Rehabilitation, ... and group-based social support when evidence-based behavioral change techniques are used 103, 104, 105. Cardiac rehabilitation (CR) is an evidence-based intervention that uses patient education, health behavior modification, and exercise training to improve secondary prevention outcomes in patients with cardiovascular disease. Carvalho T, Gonzales AI, Sties SW, Carvalho GM. Please enable it to take advantage of the complete set of features! Short-Term Exercise Progression of Cardiovascular Patients throughout Cardiac Rehabilitation: An Observational Study. Setting and delivery of preventive car-diology. Epub 2020 May 1. They differ from the traditional models of CR, which are generally organised in three phases (e.g., post-intervention on the ward, post-discharge and long-term), involving residential, ambulatory community-, or home-based programmes. Acknowledging the formally shared responsibilities of all professionals involved in a cardiac patient’s care (nurses, general practitioners, intensivists, acute invasive cardiologists and cardiovascular surgeons), the ­European Association for Preventive Cardiology (EACP), the Acute Cardiovascular Care Association (ACCA) and the Council on Cardiovascular Nursing and Allied Professions (CCNAP) started a collaborative project to increase awareness of the various gaps and how possibly to overcome them. Cardiac rehabilitation (CR) is an evidence-based intervention that uses patient education, health behavior modification, and exercise training to improve secondary prevention outcomes in patients with cardiovascular disease. In order to offer you a better user experience, we use cookies. New delivery strategies are urgently needed to improve participation. CR programs reduce morbidity and mortality rates in adults with ischemic heart disease, heart failure, or cardiac surgery but are significantly underused, with only a minority of eligible … However, important lines of inquiry remain and require attention. Structured cardiac rehabilitation (CR) programmes are recognised as the clinical setting for implementation of such a preventive care strategy [1]. Eur J Cardiovasc Prev Rehabil. Arq Bras Cardiol. 2018;21(02):48-52. Hospital-based rehabilitation units. It is the process by which cardiac patients recover and readapt to reach and maintain optimal physical, sensory, intellectual, psychological and social functional levels through strategies such that they are provided with the tools to resume their ordinary activities as soon as possi… 6 Doherty P, Lewin R. The RAMIT trial, a pragmatic RCT of cardiac rehabilitation versus usual care: what does it tell us? Circulation. Investigators B-. As such, evidence-based practice features strongly together with multidisciplinary approaches to the comprehensive delivery of high-quality care. In order to achieve the proven effectiveness of CR in routine clinical practice, the definition, implementation and continuous monitoring of accepted minimal standards for CR delivery are constantly reviewed by the BACPR. As the basis for the elaboration of their recommendations, the BACPR used the following definition: CR is the “coordinated sum of activities required to influence ­favourably the underlying cause of cardiovascular disease, as well as to provide the best possible physical, mental and social conditions, so that the patients may, by their own efforts, preserve or resume optimal functioning in their community and through improved health behaviour, slow or reverse progression of disease”. Therefore, in the most recent European Guidelines on cardiovascular disease prevention in clinical practice, alternative rehabilitation models are rated as follows [4]: – Home-based rehabilitation with or without tele­monitoring holds promise for increasing participation and supporting behavioural change. Published under the copyright license “Attribution – Non-Commercial – NoDerivatives 4.0”. Keywords: Several systematic reviews have explored quantitative evidence on the potential of digital interventions to support cardiac rehabilitation (CR) and self-management. This site needs JavaScript to work properly. Journal of Cardiopulmonary Rehabilitation and Prevention. Correspondence:Jean-Paul Schmid, MDCardiology, ­Klinik ­BarmelweidCH-5017 Barmelweidjean-paul.schmid[at]barmelweid.ch. Challenges in secondary prevention after acute myocardial infarction: A call for action. 2016;23(18):1914–39. Continuity of care and outpatient management for patients with and at high risk for cardiovascular disease during the COVID-19 pandemic: A scientific statement from the American Society for Preventive Cardiology. Cardiovascular Medicine. Eur J Heart Fail. NLM Cardiac Rehabilitation Section EAoPCicwtIoMB, Informatics DoMBUoH, the Cochrane M, Endocrine Disorders Group IoGPH-HUDG. Open Heart. De Cannière H, Smeets CJP, Schoutteten M, Varon C, Morales Tellez JF, Van Hoof C, Huffel SV, Groenendaal W, Vandervoort P. J Clin Med. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts): Developed with the special contribution of the European Association for Cardiovascular ­Prevention & Rehabilitation (EACPR). Home-Based Cardiac Rehabilitation: A Scientific Statement From the American Association of Cardiovascular and Pulmonary Rehabilitation, the American Heart Association, and the American College of Cardiology. 3 Sagar VA, Davies EJ, Briscoe S, Coats AJ, Dalal HM, Lough F, et al. Their conclusions on the current evidence of best practice have been summarised in a position paper, which provides a pragmatic summary of the minimum standards, structure and function of cardiovascular prevention and rehabilitation programmes (http://www.bacpr.com/resources/AC6_BACPRStandards&CoreComponents2017.pdf) (table 1). The effect of CR on recurrent myocardial infarction and repeat revascularisation seems to be neutral; however, there is a significant reduction in acute hospital admissions (from 30.7 to 26.1%, NNT 22), which is a key determinant of the intervention’s overall cost-efficacy [2]. 2015;22(12):1548–56. Thomas RJ, Beatty AL, Beckie TM, Brewer LC, Brown TM, Forman DE, Franklin BA, Keteyian SJ, Kitzman DW, Regensteiner JG, Sanderson BK, Whooley MA. In Switzerland, the definition of and compliance with the national quality standards, including the maintenance of a national database, is ensured by the Swiss working group for Cardiovascular Prevention, Rehabilitation and Sports Cardiology (SCPRS). 2020 Nov;73(11):969-970. doi: 10.1016/j.recesp.2020.06.040. Heart. In 1982, Medicare policies provided for coverage of cardiac rehabilitation (CR) for patients recovering from myocardial infarction or coronary artery bypass graft surgery (CABG) or for those with stable angina. It is clear that ineffective delivery of CR is not a problem specific to the UK, and their standards should be taken as an example for the whole of Europe. Cardiac rehabilitation, telemedicine, telehealth, secondary prevention, cardiovascular. Epub 2020 Sep 14. 4 Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, Catapano AL, et al. Increasing exercise capacity and quality of life of patients with heart failure through Wii gaming: the rationale, design and methodology of the HF-Wii study; a multicentre randomized controlled trial. https://doi.org/10.4414/cvm.2018.00545 2012;98(8):605–6. Previous randomized trials have generated low- to moderate-strength evidence that HBCR and center-based CR can achieve similar improvements in 3- to 12-month clinical outcomes. Available literature on barriers to the accessibility of out-patient cardiac rehabilitation services were reviewed. A position paper from the Cardiac Rehabilitation Section of the European Association of Cardiovascular Prevention and Rehabilitation. 2015;17(7):743–8. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Rich MW, Chyun DA, Skolnick AH, Alexander KP, Forman DE, Kitzman DW, Maurer MS, McClurken JB, Resnick BM, Shen WK, Tirschwell DL. The BLITZ-4 Registry. 2016 Nov;64(11):2185-2192. doi: 10.1111/jgs.14576. 2012 Nov 20;126(21):2535-43. doi: 10.1161/CIR.0b013e318277728c. NIH Accessibility to those services is a major factor in the underutilisation of current programs. However, because it was greatly underpowered (having recruited at best only 23% of the original predefined sample in each trial arm), RAMIT cannot be viewed as a trial of “efficacy”, that is, to demonstrate whether or not CR “works”, but as a pragmatic trial of its effectiveness as provided “in real life” [1].It raised concerns due to considerable ­differences between the centres that recruited patients with respect to content, duration, intensity and volume of the intervention offered to patients. Access to a health coach for HBCR participants has potential to improve communication, social support, and education, which can help sustain … 5 Rauch B, Davos CH, Doherty P, Saure D, Metzendorf MI, Salzwedel A, et al. 2016 May 24;133(21):2103-22. doi: 10.1161/CIR.0000000000000380. Cardiac Rehabilitation Section European Association of Cardiovascular P, Rehabilitation. Keywords: The prognostic effect of cardiac rehabilitation in the era of acute revascularisation and statin therapy: A systematic review and meta-analysis of randomized and non-randomized studies – The Cardiac Rehabilitation Outcome Study (CROS). Eur J Prev Cardiol. The effective implementation of intensive lifestyle and medical risk factor management together with enabling psychosocial health and wellbeing are … Rev Esp Cardiol. Epub 2012 Oct 22. AHA Scientific Statements; behavior therapy; cardiac rehabilitation; exercise; patient education. 2020 Mar;1:100009. doi: 10.1016/j.ajpc.2020.100009. However, only the community- and telehealth-based individualised and multifactorial models for CR were found in studies to be associated with improvements in cardiovascular disease risk factor profile similar to those with the traditional hospital-based approach. A recent trial in a cohort of 2,787 patients from 21 centres showed that CARDSS increases the compliance with guideline-recommended therapeutic decisions . Evidence to be reviewed included clinical practice guidelines available in English or Japanese and existing quality indicators. This guideline provides evidence-based recommendations and best practice guidance on the management of patients referred for cardiac rehabilitation. No commercial reuse without permission. Eur J Cardiovasc Prev Rehabil. For Switzerland, no reliable numbers regarding referral of patients to CR services exist. Cardiac Rehabilitation Section of the European Association of Cardiovascular P, Rehabilitation. The following are key points to remember from this Scientific Statement on home-based cardiac rehabilitation (CR): CR is an evidence-based intervention that utilizes patient education, health behavior modification, and exercise training to improve secondary prevention outcomes in patients with established cardiovascular disease. 2020 Sep;9(17):e017075. Performance of each indicator was assessed retrospectively using medical records at a university hospital in Japan. Phase III or IV cardiac rehabilitation programs, Outpatient Intensive Cardiac Rehabilitation programs 2020 Sep 29;9(10):3160. doi: 10.3390/jcm9103160. 7 Bjarnason-Wehrens B, McGee H, Zwisler AD, Piepoli MF, Benzer W, Schmid JP, Det al. Clinical Implications of Physical Function and Resilience in Patients Undergoing Transcatheter Aortic Valve Replacement. 11. +41 (0)61 467 85 55 Fax +41 (0)61 467 85 56 e-mail: Editorial office, EMH MediaSchweizerische ÄrztezeitungSwiss Medical ForumSwiss Medical WeeklyPrimary and Hospital CareSwiss Archives of Neurology, Psychiatry and PsychotherapySynapseSwiss Medical Informatics. More than 3,600 people participate in the program annually, with 70% acceptance rates and 60% completion rates. Lifestyle changes, including healthy food intake, regular physical activity and long-term adherence to optimal cardioprotective medication, are the main pillars of the long-term management of atherosclerotic disease. Despite the evidence to support cardiac rehabilitation, existing services remain underutilised. Centre-based, multidisciplinary cardiac rehabilitation programmes complying with well-defined minimal requirements are the gold standard for de­livering optimal postinterventional care and achieving secondary preven­-tion goals. 2013;101(6):e107–8. Cardiac rehabilitation (cardiac rehab) is a program of exercise, education and counselling designed to help you recover after a heart attack or other heart conditions.This personalized program will help you regain your strength, prevent your condition from getting worse and reduce your risk of having heart problems in the future. CR has been shown to reduce mortality, hospital readmission rates, healthcare costs and also to improve exercise capacity, quality of life and the … Robust evidence demonstrates positive effects of CR participation, including reductions of mortality up to 25% as well as decreases in hospitalizations . Goel K, O'Leary JM, Barker CM, Levack M, Rajagopal V, Makkar RR, Bajwa T, Kleiman N, Linke A, Kereiakes DJ, Waksman R, Allocco DJ, Rizik DG, Reardon MJ, Lindman BR. Cardiac rehabilitation in Europe: results from the European Cardiac Rehabilitation Inventory Survey. Intensive Cardiac Rehabilitation is aimed for the reduction of Triglycerides levels, Body mass index levels, Systolic & Diastolic blood pressure levels, LDL levels. However, although promising, evidence regarding the effectiveness and uptake of existing interventions is mixed. The quality standards and adherence to the guidelines are monitored by means of regular audits. King M, Bittner V, Josephson R, Lui K, Thomas RJ, Williams MA. This second edition of the Standards and Core Components (SCC) for Cardiovascular Disease Prevention and Rehabilitation from the British Association for Cardiovascular Prevention and Rehabilitation (BACPR) define cardiac rehabilitation (CR), operationally, through seven standards and seven core components for assuring a quality service of care using a multidisciplinary biopsychosocial … Lifestyle risk factor management – Physical activity and exercise training – Healthy eating and body composition – Tobacco cessation and relapse prevention, Failure to identify and manage comorbid conditions, Poor communication between physician and others ­involved in a patient’s healthcare provision, Pressure to shorten length of hospital stay, Healthcare systems focused on acute care (hospital-based health systems), Depression, mental disease, substance abuse, Poor awareness on value of preventive measure, Low health literacy / poor awareness on ­value of preventive measure, Poorly designed preventive programmes / lack of quality control. 2010;17(1):1–17. Expert Rev Cardiovasc Ther. – Home-based rehabilitation programmes have the potential to increase patient participation by offering greater flexibility and options for activities. J Am Heart Assoc. Electronic searches of Medline, Embase, CINAHL, science citation … Epub 2019 May 13. In the interim, we conclude that HBCR may be a reasonable option for selected clinically stable low- to moderate-risk patients who are eligible for CR but cannot attend a traditional center-based CR program. Khera A, Baum SJ, Gluckman TJ, Gulati M, Martin SS, Michos ED, Navar AM, Taub PR, Toth PP, Virani SS, Wong ND, Shapiro MD. Starting from simple bedside consultations lasting a few minutes, they have evolved into professionally led multidisciplinary interventions within CR services. J Am Geriatr Soc. In the meantime, alternative forms of endurance training, such as ballroom dancing or, for example, exergaming [11, 12] could be considered in order to increase the attractiveness of the services and to contribute to overcoming some of the barriers to participation and long-term adherence. 12 Jaarsma T, Klompstra L, Ben Gal T, Boyne J, Vellone E, Back M, et al. Thomas, Randal J.; Beatty, Alexis L.; Beckie, Theresa M.; More. [Exercise-based cardiac rehabilitation in COVID-19 times: one small step for health care systems, one giant leap for patients]. Epub 2020 Aug 28. 1 Another German physician, Peter Beckman, … Multidisciplinary cardiac rehabilitation (CR) reduces morbidity and mortality and increases quality of life in cardiac patients [2,3,4].Outpatient CR is a comprehensive intervention, in which patients are offered an individualised centre-based programme that may consist of one or more group-based modules or therapies (i.e. This article updates the American Heart Association (AHA) 1994 scientific statement on cardiac rehabilitation. Cardiovascular Medicine EMH Swiss Medical Publishers Ltd. Farnsburgerstrasse 8 CH-4132 Muttenz Tel. Scientific evidence for cardiac ­rehabilitation A multitude of individual studies and meta-analyses document the beneficial effects of CR programmes in patients with coronary artery disease with or without heart failure. Although the CR community still struggles to achieve optimal service delivery, secondary prevention measures have greatly improved over recent decades. Clipboard, Search History, and several other advanced features are temporarily unavailable. Epub 2016 Apr 11. For historical, structural or logistical reasons, settings of CR vary in different countries across Europe [7]. 8 Urbinati S, Olivari Z, Gonzini L, Savonitto S, Farina R, Del Pinto M, et al. Intensive Cardiac Rehabilitation is different from the traditional cardiac rehab. J Cardiopulm Rehabil Prev. Swiss Archives of Neurology, Psychiatry and Psychotherapy, Scientific evidence for cardiac ­rehabilitation, Minimal standards and core components of CR programmes, Barriers to the implementation of ­secondary prevention. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Home-Based Cardiac Rehabilitation: A SCIENTIFIC STATEMENT FROM THE AMERICAN ASSOCIATION OF CARDIOVASCULAR AND PULMONARY REHABILITATION, THE AMERICAN HEART ASSOCIATION, AND THE AMERICAN COLLEGE OF CARDIOLOGY . 1 It provides a review of the recommended components of optimal rehabilitation/secondary prevention programs, ways to deliver these services, recommended future research directions, and the rationale for these recommendations, with emphasis on the exercise … Eur J Prev Cardiol. In contrast to center-based CR services, which are provided in a medically supervised facility, HBCR relies on remote coaching with indirect exercise supervision and is provided mostly or entirely outside of the traditional center-based setting. National Campaign for Cardiac Rehabilitation The Evidence Rehab Cardiac Rehab Rehab Cardiac Rehab Rehab. Accordingly, the most recent European Guidelines on cardiovascular disease prevention in clinical practice state that in individuals at very high cardiovascular risk, multimodal interventions integrating medical resources with education on healthy lifestyle, physical activity and stress management, and counselling on psychosocial risk factors, are recommended with a class I, evidence A indication [4]. • new evidence of ischemia on an exercise test, including thallium scan • new, clinically significant coronary lesions documented by cardiac catheterization . A platform for postgraduate education and scientific work. Whereas the aims of outpatient and residential inpatient programmes in terms of secondary prevention are identical, the latter are specifically structured to provide ongoing medical care and individualised training, reserved for high-risk patients or for those for whom the attendance of an ambulatory programme is for various reasons impossible [10]. DOI: Although structured, exercise-based secondary prevention programmes as described above are the most studied modality of secondary prevention interventions in patients after an acute myocardial infarction, programme uptake and adherence proves to be particularly challenging, and innovative strategies to address these problems have been evaluated. For a successful implementation, patients need support by means of a professional multidisciplinary team, which provides the necessary information on the type and severity of their disease, initiates the required behavioural changes, and instructs the patients on how to restart physical activity after an acute coronary event or cardiovascular surgery. 9 Piepoli MF, Corra U, Dendale P, Frederix I, Prescott E, Schmid JP, et al. In fact, no benefit for survival, psychosocial status or health related quality of life was shown in that study. Regarding the situation in Switzerland, due to the short distances and a dense net of CR programmes, the need for alternative methods of CR delivery seems not to be of major importance. COVID-19 is an emerging, rapidly evolving situation. It provides recommendations on assessment, health behaviour-change techniques, lifestyle risk factor management, psychosocial health, vocational rehabilitation and medical risk management. Although a most recent meta-analysis of randomised and nonrandomised controlled studies (The Cardiac Rehabilitation Outcome Study [CROS]) confirmed a significant reduction of mortality for CR participants ­after an acute coronary syndrome or after coronary ­artery bypass surgery in prospective or retrospective cohort studies, the single randomised controlled trial available so far (RAMIT: multicentre randomised controlled trial of comprehensive cardiac rehabilitation in patients following acute myocardial infarction) showed a neutral result [5]. 2 Dalal HM, Doherty P, Taylor RS. Medical director responsibilities for outpatient cardiac rehabilitation/secondary prevention programs: 2012 update: a statement for health care professionals from the American Association of Cardiovascular and Pulmonary Rehabilitation and the American Heart Association. doi: 10.1161/JAHA.120.017075. A multitude of individual studies and meta-analyses document the beneficial effects of CR programmes in patients with coronary artery disease with or without heart failure. The evidence base supporting cardiac rehabilitation is substantial and overwhelmingly supports its utilization for all qualified patients. Upon programme completion, a final assessment of individual patient needs and demonstration of sustainable health outcomes. 1 This coverage decision was based primarily on evidence that CR provided safe and effective improvements in functional capacity and quality of life in these patients. Knowledge Gaps in Cardiovascular Care of Older Adults: A Scientific Statement from the American Heart Association, American College of Cardiology, and American Geriatrics Society: Executive Summary. These variations in funding, staffing, content of the programme and referral across CR programmes in England, Wales and Northern Ireland, where the study has been performed, have been judged unjustifiable by the British Association for Cardio­vascular Prevention and Rehabilitation (BACPR), and huge efforts have been made to ensure minimum standards, structure and function of CR programmes. Patient related factors, as well as gaps caused by healthcare providers and/or health system-based barriers are held responsible (table 3). See: emh.ch/en/emh/rights-and-licences/. The evidence-based, cardiac rehabilitation program serves patients at 17 community sites across a large region of Ontario and includes weekly visits for six months. 2019 Jul 9;74(1):133-153. doi: 10.1016/j.jacc.2019.03.008. Cardiovascular rehabilitation, ballroom dancing and sexual dysfunction. Table 2 summarises the six core components which constitute the “coordinated sum of activities” by which CR programmes should improve physical health and quality of life, as well as equip and support people in developing the necessary skills to successfully manage themselves. 2010;17(4):410–8. The purpose of this scientific statement is to identify the core components, efficacy, strengths, limitations, evidence gaps, and research necessary to guide the future delivery of HBCR in the United States. Registration and submission of data to a national audit. However, it is estimated that, of eligible patients, only 14 to 35% of heart attack survivors and 31% of patients after coronary artery bypass surgery participate in secondary prevention programmes and that 70% of suitable patients do not receive dedicated interventions for risk factor reduction [7]. To be considered in the future, new forms of CR need to achieve the same level of scientific evidence for improvement in clinical endpoints as the established methods, which constitute the gold standard. Secondary prevention through cardiac rehabilitation: from knowledge to implementation. Participants 10 professionals in cardiac rehabilitation for the consensus panel. For patients who have suffered myo­cardial infarction and/or undergone coronary revascularisation, attending and completing a programme of exercise-based CR is associated with an absolute risk reduction in cardiovascular mortality from 7.6 to 10.4% compared with those who do not take part in a CR programme, with a number needed to treat (NNT) of 37. Publication Date: Cardiac rehabilitation (CR) – a comprehensive outpatient program of secondary prevention and lifestyle changes – can mitigate this burden. Additional information can be found here. Secondary prevention after acute myocardial infarction: drug adherence, treatment goals, and predictors of health lifestyle habits. 39(4):208-225, July 2019. Exercise-based rehabilitation for heart failure: systematic review and meta-analysis. Rich MW, Chyun DA, Skolnick AH, Alexander KP, Forman DE, Kitzman DW, Maurer MS, McClurken JB, Resnick BM, Shen WK, Tirschwell DL; American Heart Association Older Populations Committee of the Council on Clinical Cardiology, Council on Cardiovascular and Stroke Nursing, Council on Cardiovascular Surgery and Anesthesia, and Stroke Council; American College of Cardiology; and American Geriatrics Society. However, despite of all available evidence, some doubts persist on the efficacy of CR in the modern era. For individuals with a diagnosis of heart failure, CR may not reduce total mortality, but does impact ­favourably on hospitalisation, with a 25% relative risk reduction in overall hospital admissions and a 39% ­reduction (NNT 18) in acute heart failure related ­episodes [3]. This program outline guide is based on the best available evidence, and has been developed in consultation with cardiac rehabilitation experts across Australia. Strategies [ 8 ] as the clinical setting for implementation of such a preventive care [... European cardiac rehabilitation: an Observational study efficacy of CR participation, including scan... Trials have generated low- to moderate-strength evidence that HBCR and center-based CR can achieve improvements...: AHA scientific Statements ; behavior therapy ; cardiac rehabilitation in Europe: results from the cardiac,! Article was reported are urgently needed to improve participation reviewed regularly it to take advantage of the Association. 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